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 TRYPANOSOMA CRUZI

Posted By Admin    on 18-06-2022    Comments (10)

TRYPANOSOMA CRUZI
• Causative agent of Chaga’s disease
• Trypomastigote form seen in peripheral blood 
• Amastigote seen intracellularly (multiplying form )
• Man gets infection by rubbing the bug faeces in the bite area
• Clinical features – chagoma (subcutaneous inflammatory nodule)
• Romana’s sign – painless,unilateral  oedema and conjuctitivits
• Complications –acute myocarditis and meningoencephalitis
• Chronic disease – conduction defects in the heart ,megaesophagus ,megacolon
• Life cycle – in man – amastigote –promastigote –epimastigote – trypomastigote
• In Reduviid bug – trypomastigote – amastigote – epimastigote –metacyclic trypomastigote form
• Lab diagnosis – 1.specimens – blood ,CSF,aspirate from Chagoma ,tissue specimen
• Microscopy – wet blood film,Giemsa stained smear
• Culture –NNN(Novy,McNeal and Nicolle)  at 22-24 deg C
• Serology – chronic cases
• Polymerase chain reaction 
• Biopsy 
• Animal inoculation (intraperitoneally into mice)
• Xenodiagnosis 

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 TRYPANOSOMA BRUCEI

Posted By Admin    on 18-06-2022    Comments (10)

TRYPANOSOMA BRUCEI

• Causative agent of Sleeping sickness disease
• Trypomastigote form (long slender form,short stumpy form,intermediate form)seen in peripheral blood 
• Clinical features –chancre (swelling and oedema of the bite area)
• Acute (early and lymphatic stage) –posterior cervical lymphadenopathy (winterbottom’s sign)
• Late phase and CNS involvement – sleeping sickness –chemical called tryptophol produced by trypanosome induce sleepiness – finally coma and death
• Transmission – through the bite of infected tsetse fly
• Life cycle – in man(definitive host) trypomastigote(long slender multiplying form )- intermediate form and short stumpy form – tsetse fly (intermediate host) –long slender form –salivary glands –convert to epimastigotes – metacyclic forms - man
• Lab diagnosis – 1.specimens – blood ,CSF,aspirate from lymph node ,tissue specimen
• Microscopy – wet blood film,Giemsa stained smear
• Culture –NNN(Novy,McNeal and Nicolle)  at 22-24 deg C
• Serology – chronic cases
• Polymerase chain reaction 
• Biopsy 
• Animal inoculation (intraperitoneally into mice)
• Xenodiagnosis 

More

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  • IMMUNOLOGY
  • Virology
  • Parasitology
  • Mycology
  • general microbiology
  • CASE BASED SERIES
  • COMPETENCY BASED EDUCATION
  • infective syndromes

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